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Stuttgart managed to maintain their Bundesliga status in dramatic fashion last season, with a final-day victory over FC Koln enough to move them out of the relegation zone.
Japanese midfielder Wataru Endo scored a 92nd-minute winner to help Die Roten climb above Hertha Berlin and avoid facing a relegation playoff on goal difference.
Stuttgart kept only five Bundesliga clean sheets last season, the joint-second fewest in the division, and head coach Pellegrino Matarazzo has opted to strengthen his backline by bringing in three new defenders including Konstantinos Mavropanos on a permanent deal from Arsenal.
Die Roten have managed to retain the services of star striker Sasa Kalajdzic for now, but his future still remains uncertain amid interest from the likes of Manchester United and Tottenham Hotspur.
Stuttgart have made a perfect start to their pre-season so far, with an emphatic 7-1 victory over Boblingen in their opening warm-up match followed by 3-2 victories against both SV Wehen Wiesbaden and FC Zurich.
Stuttgart boss Matarazzo used two almost entirely different lineups in both halves of their most recent friendly against FC Zurich and he is likely to take a similar approach to Saturday’s game.
Summer signing Josha Vagnoman is set to battle with Pascal Stenzel for a place at right wing-back this season, but the former could be handed a start on the opposite flank this weekend, as key creative outlet Borna Sosa is ruled out with a thigh injury.
Darko Churlinov and Naouirou Ahamada both came on in the second half to score in the win over Zurich, the latter of whom netting a brace, and the pair could be handed starts from the off this time around.
As for Brentford, Frank named two completely different teams in each half against Boreham Wood and could do the same again against Stuttgart.
Goalkeeper Strakosha only joined the club on Thursday but he could be involved this weekend as he is set to join up with the rest of the squad in Germany.
The likes of Ivan Toney, Sergi Canos, Rico Henry, Pontus Jansson and Vitaly Janelt were all given run-outs last time out and they are expected to feature again at some stage on Saturday.
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Frank has confirmed, however, that defender Kristoffer Ajer will not be involved in pre-season and will miss their Premier League opener against Leicester after undergoing hamstring surgery.
Stuttgart possible starting lineup:
Muller; Mavropanos, Anton, Ito; Stenzel, Ahamada, Endo, Vagnoman; Churlinov, Fuhrich; Kalajdzic
Brentford possible starting lineup:
Balcombe; Sorensen, Jansson, Racic; Stevens, Janelt, Baptiste, Dasilva, Hickey; Lewis-Potter, Toney