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Barnsley sacked Poya Asbaghi after their relegation was confirmed last week, with caretaker boss Martin Devaney overseeing a 2-0 home defeat to Blackpool on Tuesday night.
Devaney, who made over 170 appearances for the club as a player, is the favourite to take the job full time and gave opportunities to a few younger names on Tuesday with a view to planning for next season.
The Tykes are dropping out of the Championship without a whimper – 12 months after competing in the playoffs for promotion to the Premier League – as they have not won in their last seven matches and are currently on a run of three consecutive defeats.
Twenty-two of their 30 points this season have come at Oakwell, so with a trip to West Bromwich Albion to come on the final day, their last chance to give fans something to smile about is likely to come this weekend on home turf.
Barnsley are already planning for next season, with loanees Claudio Gomes, Amine Bassi and Domingos Quina returning to their parent clubs early.
The Tykes have also pledged to only use players contracted beyond the end of the season, meaning Aapo Halme, Romal Palmer and Victor Adeboyejo are unlikely to feature.
Youngsters Isaac Christie-Davies, William Hondermarck and Aiden Marsh all played against Blackpool and should get game time again.
Ryan Lowe has confirmed that out-of-contract Izzy Brown and loanee Josh Murphy are no longer training with Preston as they have failed to meet his “high standards”.
Having returned from a calf injury, Tom Barkhuizen played 45 minutes for the reserve side on Tuesday and is in contention to play.
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Andrew Hughes has a toe problem and is a doubt, while Ched Evans is unlikely to feature as his recovery from injury continues.
Barnsley possible starting lineup:
Walton; Moon, Kitching, Andersen; Brittain, Wolfe, Hondermarck, Oduor; Styles; Woodrow, Morris
Preston North End possible starting lineup:
Iversen; van den Berg, Lindsay, Bauer; Potts, McCann, Browne, Cunningham; Johnson; Riis, Archer