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So they will be keen to get their play-off quest back on track when Wycombe visit the south coast on Saturday (3pm kick-off).
The Chairboys are also battling it out for a place in the end of season lottery, currently sitting a single point behind sixth-placed Sunderland.
Jason McCarthy’s strike deep into stoppage-time earned them a valuable victory against Fleetwood on home soil on Tuesday night.
It means that Gareth Ainsworth’s men have not lost any of their past four fixtures – a sequence that includes three successes and a draw with summit sitters Rotherham.
They are searching for an instant return to the Championship after suffering relegation on the final day of last season.
A depleted Pompey side emerged 1-0 winners when the sides met at Adams Park back on November.
Marcus Harness bundled home the only goal in the second half after Alex Bass had kept out a Joe Jacobson penalty.
The most recent Fratton Park contest took place on Boxing Day on 2019, as Ben Close and Ronan Curtis found the target to provide some festive cheer for the Blues.
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Pompey will welcome Marcus Harness back to the squad after the forward completed a three-match suspension.
But Kieron Freeman (ankle), Reeco Hackett (knee), Jayden Reid (knee) and Shaun Williams (back) remain sidelined.