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Wigan are currently on a remarkable 20-match unbeaten run in all competitions, which has propelled them into the automatic promotion mix in League One.
The run also includes FA Cup wins over Solihull Moors, Colchester United and then Championship side Blackburn Rovers in round three.
This is the Latics’ first appearance in the fourth round since 2018 and since famously beating Manchester City to win the 2013 final, they have only reached round five on two occasions.
Leam Richardson‘s side have the best away record in League One this season and have only lost twice on the road throughout the whole campaign.
Three of Stoke’s January arrivals – Phil Jagielka, Lewis Baker and Jaden Philogene-Bidace – will all be unavailable for this game as they are cup-tied.
However, there could be debuts for deadline day signings Josh Maja and Liam Moore, who have no such issues.
Goalkeeper Joe Bursik is in contention to feature having recovered from a muscle injury that has ruled him out since the beginning of November, while Mario Vrancic will be assessed after being forced off against Huddersfield Town last weekend.
Wigan have been dealt a blow by the news that top scorer Will Keane will miss the game due to a hamstring injury, while defender Tom Pearce is also out.
January signing Graeme Shinnie is cup-tied, but deadline day recruits Jamie McGrath and Glen Rea could make their debuts.
James McClean will be eager to feature against his former club, but fellow ex-Potter Jordan Cousins has a long-term thigh injury.
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Stoke City possible starting lineup:
Bursik; Wilmot, Chester, Fox; Smith, Allen, Powell, Thompson, Tymon; Wright-Phillips, Brown
Wigan Athletic possible starting lineup:
Jones; Tilt, Watts, Whatmough; Power, Naylor, Rea, Darikwa; Lang, Magennis, McClean
Wigan won 3-0 in the last fixture between these two sides when they met in the Championship in June 2020 – the Latics’ points deduction for going into administration relegated them three weeks later.