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Man United made it three wins in their last four matches in all competitions when they beat West Ham United 1-0 before the break, with Marcus Rashford‘s last-gasp winner securing a vital three points for the Red Devils, who currently occupy fourth position in the Premier League table.
Ralf Rangnick‘s side also overcame Brentford in the league on January 19, while they booked their spot in the fourth round of this season’s FA Cup courtesy of a 1-0 success over Aston Villa at Old Trafford.
Off-the-field matters involving Mason Greenwood means that the build-up to this match has been overshadowed, but the players will be raring to go following a short break, and the Red Devils are still fighting on three fronts this season, with the first leg of their last-16 Champions League contest with Atletico Madrid due to take place at Wanda Metropolitano on February 23.
Man United are the second-most successful side in the history of the FA Cup, winning the competition on 12 occasions, the last of which was in 2016, while they lost in the quarter-finals to Leicester City last season and Chelsea in the semi-finals of the 2019-20 campaign.
Friday’s contest will be the first time that the 20-time English champions have faced Middlesbrough since a Premier League contest in March 2017, with the Red Devils running out 3-1 winners at the Riverside Stadium courtesy of goals from Marouane Fellaini, Jesse Lingard and Antonio Valencia.
Man United interim head coach Rangnick has said that Paul Pogba and Luke Shaw will both be involved on Friday following spells out, while Aaron Wan-Bissaka should be available following a period on the sidelines through illness.
Jadon Sancho should also be included in the squad following personal issues, but Edinson Cavani will not feature due to his involvement for Uruguay over the international break, while Victor Lindelof (illness), Eric Bailly (ankle) and Jesse Lingard (personal) are all out.
Greenwood has been suspended by the club and will not be involved for the foreseeable future, so Rashford could feature on the right, while Nemanja Matic and Anthony Elanga should both start.
Rangnick will certainly have one eye on the Premier League clash with Burnley on February 8, but Cristiano Ronaldo is expected to start for the Red Devils, while David de Gea could retain his spot between the sticks despite the presence of Dean Henderson, who has hardly been involved this term.
As for Middlesbrough, new signing Riley McGree has tested positive for coronavirus while on international duty with Australia, so he will not be involved in this match.
Sammy Ameobi, Darnell Fisher and Marc Bola remain on the sidelines, while James Lea Siliki is still on international duty, but on-loan Arsenal striker Folarin Balogun is expected to make his first start for the club.
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Wilder is likely to select a strong side at Old Trafford, with Andraz Sporar potentially joining Balogun in the final third of the field, but the likes of Duncan Watmore, Lee Peltier and Martin Payero will also be hoping to be given minutes in the FA Cup contest.
Manchester United possible starting lineup:
De Gea; Dalot, Varane, Maguire, Shaw; Matic, McTominay; Rashford, Fernandes, Elanga; Ronaldo
Middlesbrough possible starting lineup:
Lumley; McNair, Bamba, Fry; Jones, Howson, Crooks, Tavernier, Taylor; Sporar, Balogun