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Having witnessed Rovers record their heaviest home league defeat in their entire history, Tony Mowbray knows that he has work to do in order to lift the mood at Ewood Park.
Rovers were already two goals behind against Fulham when Jan Paul van Hecke was deservedly sent off for a high challenge on the halfway line, a rush of blood which played its part in five goals being shipped during the second half.
Regardless of the circumstances surrounding their capitulation, Mowbray will be aware that his players need a response on Saturday to avoid the frustration of their most recent defeat lingering during the international break.
There have been more positives than negatives of late, too, with Rovers still collecting 12 points from their last six Championship fixtures.
Despite dropping down to mid-table, Blackburn only sit two points adrift of fifth-placed Queens Park Rangers.
If Daniel Ayala fails to shake off a calf injury, Hayden Carter is expected to deputise for Van Hecke in the Blackburn defence.
Further alterations are expected with Sam Gallagher potentially being in a position to return in attack after a knock.
Leighton Clarkson is an alternative in midfield with Mowbray likely to consider introducing fresh legs.
Billy Sharp could return to the Sheffield United XI, taking the place of Lys Mousset in attack.
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Iliman Ndiaye may also come back into the side, Rhian Brewster the most likely to drop out with Gibbs-White moving back out wide.
Blackburn Rovers possible starting lineup:
Kaminski; Nyambe, Lenihan, Carter, Edun; Travis, Clarkson, Rothwell; Dolan, Gallagher, Brereton
Sheffield United possible starting lineup:
Olsen; Bogle, Basham, Egan, Stevens; Norwood, Fleck; Gibbs-White, Ndiaye, Osborn; Sharp