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Genk kickstarted the Europa League with confidence by defeating Rapid Wien 1-0, but that has since been followed up by two defeats which have sunk them to the bottom of Group H.
Both of those games resulted in 3-0 losses, with Dinamo Zagreb and West Ham United picking up points comfortably against them, which is something that John van den Brom would like to change.
The last meeting between these teams saw the Hammers perform dominantly, with goals from Craig Dawson, Issa Diop and Jarrod Bowen helping to secure the victory.
However, since that fixture, Genk have won every game that they have played, doing so with real flair and attacking prowess, which should have instilled some confidence into the squad.
The past three matches have seen the team score 12 goals, showcasing their ability in front of goal which needs to be transferred into this competition, where they have found the back of the net just once.
Genk will once again be without Daniel Munoz as he serves the last game of his suspension, and that will provide an opportunity for Angelo Preciado to step in and play at right-back.
Aside from that, there might not be too many changes to the team that won 6-2 on Sunday, and with no travel to contend with, the team should benefit from being slightly sharper.
For West Ham, this could be an opportunity to shake the pack a little, with Vladimir Coufal potentially earning his first start since returning from injury in the EFL Cup.
However, with Ben Johnson finding the back of the net on Sunday, he might have done enough to prove to Moyes that he deserves to keep his place in the squad.
Michail Antonio will lead the line for the club, while Alex Kral could be given the chance to play following his isolation due to COVID-19.
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Mark Noble is also an option for the Hammers as he did not feature in the Premier League at the weekend, with the experienced midfielder being fresh for this game.
Genk possible starting lineup:
Vandervoordt; Arteaga, Lucumi, Sadick, Preciado; Heynen, Hrosovsky, Thorstvedt; Paintsil, Ito, Onuachu
West Ham United possible starting lineup:
Fabianski; Coufal, Zouma, Ogbonna, Cresswell; Rice, Soucek; Bowen, Benrahma, Fornals; Antonio