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Atalanta took a two-goal lead at Old Trafford in the reverse fixture on October 20, with Mario Pasalic and Merih Demiral on the scoresheet, but Man United hit back in spectacular fashion, scoring through Marcus Rashford, Harry Maguire and Cristiano Ronaldo to secure all three points on home soil.
The result has left the Italian outfit in third position in Group F, level on points with second-placed Villarreal and just two behind leaders Man United, which is an indication of the importance of Tuesday’s contest.
Atalanta have played three Serie A matches since the clash in Manchester, drawing with Udinese and Lazio, in addition to recording a 3-1 victory at Sampdoria, and a total of 19 points from 11 matches, collected through five wins and four draws, has left them in fifth position in the table.
Gian Piero Gasperini‘s side have reached the quarter-finals and round of 16 in the last two seasons of the Champions League, but they have only won three of their nine home fixtures in the competition, one of which was a 1-0 success over Young Boys at the end of September.
The Italian giants will finish their Group F campaign with clashes against Young Boys (A) and Villarreal (H), and it will be fascinating to see how the section develops over the next few weeks, as all four teams will still be confident of challenging for a spot in the knockout round of the competition.
A 3-4-3 formation should see Duvan Zapata operate at the tip of the attack, with Pasalic and Josip Ilicic operating in the deeper areas, although Luis Muriel and Ruslan Malinovskyi are also pushing for starts.
Man United, meanwhile, will be without the services of Victor Lindelof due to a knock, but Paul Pogba is available for selection, as his suspension only relates to domestic fixtures.
There is every chance that Solskjaer will stick with the same 3-5-2 formation that proved successful at Spurs, but it does seem likely that there will be at least two changes ahead of the Manchester derby, with Cavani potentially being protected ahead of starting on Saturday.
Meanwhile, Lindelof’s absence could see Luke Shaw feature as one of the three centre-backs, allowing Alex Telles to come into the side at wing-back.
Rashford came off the bench to score against Spurs and could join Ronaldo in attack, while Pogba and Nemanja Matic are options in the middle of the park.
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The importance of this match means that Solskjaer cannot take any real chances, though, and the XI is expected to be very similar to the one that featured at the Tottenham Hotspur Stadium.
Atalanta BC possible starting lineup:
Musso; Lovato, Demiral, De Roon; Zappacosta, Freuler, Koopmeiners, Maehle; Ilicic, Zapata, Pasalic
Manchester United possible starting lineup:
De Gea; Maguire, Varane, Shaw; Wan-Bissaka, Fernandes, McTominay, Fred, Telles; Ronaldo, Rashford