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Kane was substituted in injury time last week after injuring his ankle and is unlikely to play any part in this one, joining Ben Davies on the sidelines, although Matt Doherty could return.
Will Smallbone, Michael Obafemi and Oriol Romeu are long-term absentees for the Saints, meaning Ralph Hasenhuttl has no new injuries to contend with.
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Spurs’ challenge for the top-four has fallen by the wayside in recent weeks with the club picking up only five points from the last available 15, but the saving grace is that they are at least having no trouble in finding the net.
They have scored eight times across those five matches and going back even further, have failed to strike in only one of their most recent 11 Premier League matches so should have little trouble breaching a Southampton defence with only one clean sheet in their last 14 top-flight fixtures.
No team has conceded more away goals this season than the 36 Saints have shipped, with 26 of those coming in the eight away games they have played in 2021.
Spurs to score over 1.5 goals is priced at 8/11 (1.73) and despite appearing skinny, actually offers decent value for punters after paying out in four of Tottenham’s last six in the Premier League and with Southampton conceding more than once in each of their last four top-flight games.