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Both teams are playing for pride as the Championship season draws to a close, with another season in the second tier all but secured for the visitors as they sit nine points from the drop.
Stoke City endured a torrid visit against Birmingham City last time out, losing 2-0 to their Midlands rivals. They have won just two of their last six games, a poor run which now sees them in 12th spot.
Assistant manager Billy McKinlay left his role in the week and was replaced by former Bristol City boss Dean Holden.
Preston North End have also been in poor form, winning just one of their previous eight, but interim manager Frankie McAvoy has brought a refreshed feeling of optimism to the club despite the bad run.
There have been 106 previous meetings between the sides in all competitions. Stoke City have won only 36 times against Preston, while the visitors on this occasion have beaten their rivals on 48 occasions.
However, the Potters secured a 1-0 win in Preston last September, ending a run of three consecutive losses to the Lilywhites