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Tom Cleverley is back available for Watford after returning to training this week, while Ismaila Sarr will undergo a late fitness test after struggling with a hamstring issue.
Captain Troy Deeney is moving closer to a return to action, having missed close to two months, but this game will come too soon for the striker.
Fellow attacker Sema is a major doubt, meanwhile, as he started Sweden’s World Cup qualifier against Estonia on Wednesday.
As for Wednesday, they are expected to be without a number of first-team players for this trip to Vicarage Road.
Keiren Westwood was forced to pull out of the side that beat Barnsley due to an injury in the warm-up, but he should be back involved here.
Cameron Dawson, Moses Odubajo and Chey Dunkley are all sidelined, but Joost van Aken, Jack Marriott and Sam Hutchinson have a chance of returning this week.
Striker Rhodes seems certain to lead the line after scoring three goals in his last three Championship games, which is as many as in his previous 33.
Watford possible starting lineup:
Bachmann; Femenia, Troost-Ekong, Sierralta, Masina; Chalobah, Hughes, Gosling; Pedro, Success, Gray
Sheffield Wednesday possible starting lineup:
Westwood; Urhoghide, Lees, Borner; Palmer, Pelupessy, Bannan, Reach; Paterson, Windass; Rhodes