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Bournemouth midfielder Lewis Cook has been ruled out for the remainder of the season after rupturing his ACL on Saturday, whilst Adam Smith and David Brooks are also injured.
Danny Ings and Theo Walcott are both out until after the international break for the visitors, with Michael Obafemi, Oriol Romeu and Will Smallbone all long-term absentees.
Bournemouth vs Southampton Preview
The FA Cup has been Southampton’s saving grace this season, with any aspirations of a strong Premier League finish completely dissipating thanks to just two wins in their last 17 games – stark contrast from the seven they recorded in the opening 12 matches.
Indeed, despite their poor league form, Ralph Hasenhuttl’s men have beaten fellow top-flight sides Arsenal and Wolves in the cup so far and will fancy their chances of continuing that run against a Bournemouth side that will have their minds on other things.
Although the Cherries eased past Swansea City 3-0 on Tuesday, they remain two points off the Championship play-off places and earning promotion back into the Premier League will surely be the priority.