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Plenty has changed for both of these teams since they were last in Champions League action in December, but Liverpool in particular will be hoping that the return of European football will bring about another change in fortune.
The six-time European champions have won just five of their 15 games across all competitions since their final group game, losing six times including each of their last three outings.
The most recent of those – a against Leicester City on Saturday – saw the defending English champions fall 13 points off the pace set by Manchester City, having played a game more than the leaders.
Such was the damaging nature of the defeat that manager Jurgen Klopp that their title defence is now over, leaving the Champions League as their only remaining route to silverware this season.
However, the likelihood of being crowned kings of Europe for a seventh time appears to diminish with each passing game at the moment, with those three successive defeats to Brighton & Hove Albion, Manchester City and Leicester leaving Liverpool in a serious battle to secure their place in this competition again next season, yet alone win it this term.