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Vardy, 34, underwent hernia surgery in January but appeared as a substitute in Sunday’s 0-0 draw at Wolves.
“You can see what he brings to the team,” said Foxes manager Brendan Rodgers.
“We’ll definitely get him some minutes on Wednesday, whether that’s in the first period of the game, or the second, so he’ll feature at some point.
“We’ll make changes but it will be a strong 11. We have to consider the month of games and the early kick-off (against Liverpool on Saturday).”
Brighton boss Potter confirmed that the trip to the King Power Stadium had come too soon for Webster, after the 26-year-old injured his ankle against in the 1-1 draw at Burnley on Saturday.
But while the defender’s absence is likely to be restricted to just this game, March is set to be out of action for an extended period after requiring surgery on a knee injury he picked up in the 1-0 Premier League win at Liverpool.
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“Solly has had his operation and it’s gone well, that’s good for him and us,” said Potter.
The recovery will be slow but necessary, it’s a blow because he’s been really good, but that’s football.”
Leicester striker Vardy will play some part in the FA Cup tie at home to Brighton as he makes his way back from groin surgery.
“Brighton are playing as well as I can remember just now,” wrote Owen in his Bet Victor predictions blog.”Huge wins against Liverpool and Tottenham came prior to a 1-1 draw against Burnley, and despite not getting maximum points in the latter, Seagulls fans will be happy I’m sure.