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But Kyle Walker and Gabriel Jesus returned at the weekend and Ederson, Ferran Torres and Tommy Doyle are back with the squad after missing the last three games following positive tests.
However, City are without Aymeric Laporte and Nathan Ake through injury ahead of the visit of Brighton.
While Graham Potter’s side are facing a relegation battle and have won just once in their last 17 league and cup games, Guardiola has warned his players they offer a dangerous threat.
“They are a joy to watch, a joy to analyse,” he added. “At the same time when you see them you are concerned about their quality.
“I said to the players today that we will have to be in the highest standards to complete against them. They have better stats in all the departments except the final third. I am a big fan of Graham Potter.